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KMID : 0191120100250060895
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Journal of Korean Medical Science
2010 Volume.25 No. 6 p.895 ~ p.899
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The Causative Organisms of Bacterial Meningitis in Korean Children in 1996-2005
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Cho Hye-Kyung
Lee Hyun-Ju
Kang Jin-Han
Kim Kwang-Nam
Kim Dong-Soo
Kim Yun-Kyung
Kim Jeong-Soo
Kim Jong-Hyun
Kim Chang-Hwi
Kim Hwang-Min
Park Su-Eun
Oh Sung-Hee
Chung Eun-Hee
Cha Sung-Ho
Choi Young-Youn
Hur Jae-Kyun
Hong Young-Jin
Lee Hoan-Jong
Kim Kyung-Hyo
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Abstract
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Bacterial meningitis remains a serious cause of morbidity and mortality in childhood, despite the availability of effective vaccines against Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae. The purpose of this study was to analyze data on bacterial meningitis cases in Korea from 1996 through 2005. The information of all hospitalized bacteria-proven meningitis cases was obtained from 17 university hospitals nationwide. A total of 402 cases were identified. Of these, 125 (29.9%) cases were neonates. Streptococcus agalactiae was the most common bacteria responsible for 99 (24.6%) of all cases regardless of age, followed by S. pneumoniae for 91 (22.6%) and H. influenzae for 67 (16.7%) patients. The common etiology beyond the neonatal period was S. pneumoniae for 91 (33.0%) followed by H. influenzae for 63 (22.8%) patients. The overall case fatality rate was 9.4%, which was similar with that in 1986-1995. In conclusion, S. agalactiae,S. pneumoniae and H. influenzae were important etiologic agents of bacterial meningitis in children in the last 10 yrs. It is required to establish the preventive strategy of the three bacteria. The nationwide epidemiologic study should be continued to evaluate immunization strategy and efficacy.
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KEYWORD
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Meningitis, Bacterial, Etiology, Epidemiology, Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus agalactiae, Neisseria meningitidis
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